MRCP revision battle 11.4: Kallmans

Kallmans syndrome is an x-linked recessive condition caused by failure of GnRH secreting neurones to migrate to the hypothalamus.


Its features are:

• anosia
• 'delayed puberty'
• hypogonadism, crytoorchidism
• may be tall or of normal height

Investigations: blood LH/FSH/testosterone and all either normal or low


The most important complication to remember for MRCP is the increased risk of osteoporosis

Next up: Carcinoid syndrome