Tuesday, 14 September 2010

MRCP revision battle 11.4: Kallmans

Kallmans syndrome is an x-linked recessive condition caused by failure of GnRH secreting neurones to migrate to the hypothalamus.

Its features are:
  • anosia
  • 'delayed puberty'
  • hypogonadism, crytoorchidism
  • may be tall or of normal height

Investigations: blood LH/FSH/testosterone and all either normal or low

The most important complication to remember for MRCP is the increased risk of osteoporosis

Next up: Carcinoid syndrome