Thursday, 7 October 2010

MRCP revision battle 26.2: Lewy Body Dementia

Lewy Body Dementia accounts for around 20% of cases of dementia.

The key feature is Lewy Bodies (=intracytoplasmic neuronal inclusion bodies) in substantia nigra, paralimbic and neocortical areas.

Since this would obviously only be confirmed post-mortem diagnosis is made clinically:
  • Parkinsonian features
  • fluctuating cognitive loss
  • visual hallucinations

Neuroleptics must be avoided as their use would risk inducing irreversible Parkinsonism.

Treatments which may help include donepezil and rivastigmine.

Next up - malignant hyperthermia