The most 'famous' are:
- Huntingtons chorea (CAG) - covered in next battle
- Fragile X (CGG)
- Myotonic dystrophy (CTG) - covered in previous battle
- Friedreichs ataxia (GAA) - covered in battle 30.6
Two concepts to be born in mind for trinucleotide repeat disorders are:
Anticipation = the disease presents earlier and is worse in successive generations
Somatic instability = expansion increases as patient gets older
So lets briefly cover the most famous, Huntingtons...
