As the name suggests, it is a low-level paraproteinaemia of unknown relevance.
It is common, affecting around 3% of those over 70 yrs of age.
For MGUS to be diagnosed the following diagnostic criteria must be met:
- low level paraprotein (<30g/l)
- less than 10% plasma cells on BM
- no clinical evidence of myeloma.
Around 10% have myeloma at 5yrs so management tends to be yearly observation.
On to amyloidosis...