T cell disorders result in increased susceptibility to virus', mycobacteria and fungi.
Examples of T cell disorders include:
1. DiGeorge
- defect in development of thymus and 3rd/4th branchial arches
- mnemonic CATCH-22:
- cardiac abnormalities (tetralogy of fallot)
- abnormal faies
- thymic aplasmia --> lack of T cells
- cleft palate
- hypocalcaemia (due to absent parathyroids)
- 22 - recessive inheritance on chromosome 22
2. Nezelof syndrome
- absent thymus
- often some B cell involvement
3. Purine nucleoside phosphorylase deficiency
- prevents development of T cells
Onto the final battle of this dull triad - combined B and T cell disorders
