Tuesday, 2 November 2010

MRCP revision battle 40.3: Acetylator status

Many drugs are metabolised in the liver by acetylation.  However, up to 50% of the UK population is deficient in hepatic N-acetyltransferase, meaning they are likely to accumulate drugs that require acetylation.  These patients are known as slow acetylators.

Drugs affected include (PS HID):
  • procamide
  • sulfasalazine
  • hydrazaline
  • isoniazid
  • dapsone
  • sulphonamides

Now for some generalised lympadenopathy....