MRCP revision battle 40.3: Acetylator status

Many drugs are metabolised in the liver by acetylation.  However, up to 50% of the UK population is deficient in hepatic N-acetyltransferase, meaning they are likely to accumulate drugs that require acetylation.  These patients are known as slow acetylators.


Drugs affected include (PS HID):

• procamide
• sulfasalazine
• hydrazaline
• isoniazid
• dapsone
• sulphonamides

Now for some generalised lympadenopathy....