The characteristic feature of focal segmental glomerulonephritis is IgM and C3 deposits in affected areas.
Focal segmental glomerulonephritis may be primary or secondary to:
- IgA glomerulonephropathy
- Alport's syndrome
- heroin abuse
First line treatment is corticosteroids, which produce a response in around 30%.
25% of cases will progress to end stage renal failure, and if these are treated by renal transplant there is a 20-50% recurrence rate.
2% of patients suffer a rapid detioration
On that apt note lets move on to acute renal failure...