Tuesday, 9 November 2010

MRCP revision battle 44.7: Ethylene glycol poisoning

Ethylene glycol = antifreeze.

The stages of ethylene glycol poisoning are:
  1. alcohol drunk-like state
  2. metabolic acidosis with high anion gap
  3. acute renal failure

Treatment is fomepizole, an inhibitor of alcohol dehydrogenase.
The old-fashioned treatment failing this is to give lots of ethanol which competes with the ethylene glycol for liver metabolism and prevents glyclic acid being produced.

Haemodialysis is a final option.