Sunday, 14 November 2010

MRCP revision battle 49.6: Osteoporosis

Osteoporosis literally means 'porous bone'.


It is diagnosed by DEXA scan:
  • T to -1 SD = normal
  • T -1 to -2.5 SD = osteopenia
  • T below -2.5  SD = osteoporosis


Fracture risk is increased by 2x with each standard deviation of the T score.

Common fracture sites include:
  • vertebrae and neck of femur = trabecular bone
  • distal radius and humerus = cortical bone


Factors increasing the risk of OP include:
  • being slim
  • smoker
  • alcoholic
  • inactive
  • old
  • steroid use
  • early menopause
  • thyrotoxicosis
  • primary biliary sclerosis
  • cushings

Primary prevention of OP is with alendronate.



Now to the final battle of the day, osteogenesis imperfecta