90% of patients with HNPCC develop cancers, usually in the proximal colon and often poorly differentiated/highly aggressive cancers.
There is also an increased risk of breast, ovary and endometrial cancers.
HNPCC is defined by the Amsterdam criteria:
- at least 3 family members with colon cancer (one a 1st degree relative)
- at least 2 generations affected
- at least 1 diagnosed under 50 yrs of age
Thats quite enough bowels for one day, lets come up for some oxygen...