Features of paroxysmal nocturnal haemoglobinuria include:
- cola coloured/red urine in morning due to increase in RBC lysis overnight
- intravascular haemolysis
Diagnosis is by urinary haemosiderin or + Ham's test (rarely done now)
Treatment is anticoagulation, transfusions when needed and possibly the smart new monoclonal antibody called eculizimab.
Now on to the last battle and some pretty pictures...