AIHA will result in a positive direct antiglobulin test (= positive Coombs test)
AIHA is divided depending on the optimal binding temperatures of the autoantibodies to the RBCs.
Warm AIHA = 37C
- Ig G
- SLE, lymphoma, CLL, methyl dopa
- treatment: steroids, immunosupression, splenectomy
Cold AIHA = 4C
- IgM
- lymphoma, mycoplasma, EBV
- treatment: keep warm, ?chlorambucil
