Cryoglobulins may be IgG, IgM or IgA.
One third of cases are idiopathic.
Type 1 cryoglobulinaemia
- monoclonal
- high titres, usually >5mg/ml
- associated with:
- myeloma
- Waldenstroms
- features include vasculitis, ulceration and Raynaud's
Type 2 cryoglobulinaemia
- mixed mono and polyclonal
- titres usually >1mg/ml
- associated with:
- RA
- sjogrens
- lympoma
- CLL
- hep C
- HIV
- features include vasculitis, mesangiocapillary GN
Type 3 cryoglobulinaemia
- mixed polyclonal
- associated with:
- RA
- sjogrens
- SLE
- features include purpura, GN, arthritis
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