Saturday, 20 November 2010

MRCP revision battle 55.4: Cold agglutinins

Cold agglutinins are molecules, usually IgM, which act against red cells agglutinising and haemolysing them at low temperatures.

Symptoms of cold agglutinins include:
  • Raynauds
  • acrocyanosis
  • mild haemolytic anaemia

Causes of cold agglutinins include:
  • idiopathic
  • CLL
  • lymphoma
  • mycoplasma
  • coxsachie
  • mononucleosis
  • HIV

Management is to avoid cold weather.

Now to diversify to neurology....