Bartter's Syndrome is an autosomal recessive condition in which there is defective chloride reabsorption in the Na-K-2Cl channels in the loop of Henle resulting in severe hypokalaemia.
It presents in childhood with failure to thrive and polyuria/polydipsia
Blood pressure is normal/low.
There is hyperreninaemia and hypertrophy of the JGA.
Treatment is with potassium replacement and NSAIDs.
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