Thursday, 14 October 2010

MRCP revision battle 29.7: Bartter's Syndrome

Bartter's Syndrome is an autosomal recessive condition in which there is defective chloride reabsorption in the Na-K-2Cl channels in the loop of Henle resulting in severe hypokalaemia.

It presents in childhood with failure to thrive and polyuria/polydipsia

Blood pressure is normal/low.

There is hyperreninaemia and hypertrophy of the JGA.

Treatment is with potassium replacement and NSAIDs.

Next... Gitelman Syndrome....