Vincristine
- Inhibits microtubule formation
- Used in:
- lyphoma
- leukaemia
- breast and lung cancer
- Side effects
- peripheral paraesthesia
- loss of tendon reflexes
- abdominal pain
Cisplatin
- Cross-links DNA
- Used in:
- testicular, cervical, bladder, lung, head and neck cancers
- Side effects
- nephrotoxic
- ototoxic
- peripheral neuropathy
- hypomagnesaemia
- myelosupression
Bleomycin
- Degrades DNA
- Used in:
- metastatic germ cell cancers
- non-Hodgkins lymphoma
- Side effects
- increased pigmentation
- pulmonary fibrosis
Doxorubicin
- inhibits RNA/DNA synthesis
- used in:
- leukaemia
- lyphoma
- breast cancer
- Side effects
- red colouration of urine
- SVT
- cardiomyopathy
Methotrexate
- inhibits dihydrofolate reductase
- used in:
- non-Hodkins lymphoma
- choriocarcinoma
- RA
- Side effects
- excreted by kidneys so should be avoided in renal disease
- should be avoided in significant ascites/pleural effusion as may accumulate then suddenly return to circulation causing myelosupression
- myelosupression
- mucositis
- pneumonitis
Cyclophosphamide
- alkylating --> cross links DNA. Inactive until metabolised by liver
- used in:
- CLL
- lymphoma
- sarcoma
- Side effects
- haemorrhagic cystitis
To continue the randomness of the 46th set of battles lets look at congential infections
