There are 3 subtypes:
- subendothelial immune deposits
- caused by cryoglobulinaemia, hepatitis C
- also associated with:
- hep B
- bacterial endocarditis
- sickle cell disease
- intramembranous electron-dense material --> 'double tramline'
- associated with partial lipodystrophy
- C3b nephritic factor present in 70%
- low C3
- associated with hepatitis B and C
Treatment is with steroids
50% of patients progress to end stage renal failure.