MRCP revision battle 47.1: Membranous glomerulonephritis
MRCP revision battle 47.2: Diffuse proliferative glomerulonephritis
MRCP revision battle 47.3: Acute interstitial nephritis
MRCP revision battle 47.4: Chronic interstitial nephritis
MRCP revision battle 47.5: Alport's syndrome
MRCP revision battle 47.6: Renal papillary necrosis
MRCP revision battle 47.7: Mesangiocapillary glomerulonephritis
MRCP revision battle 47.1: Membranous glomerulonephritis
Membranous glomerulonephritis is the commonest cause of nephrotic syndrome in adults, accounting for around 30% of cases.
Peaks in incidence of membranous glomerulonephritis occur in the 2nd and 6th decade of life.
The key feature is IgG and C3 on the basemement membrane
The complication to be aware of is renal vein thrombosis which occurs in 5% of cases.
Secondary causes of membranous glomerulonephritis include:
- malignancy
- connective tissue disease: RA/SLE/sjogrens
- infection: HBV/HCV/malaria/syphilis
- drugs: NSAIDs/gold/penicillamine/captopril
- other: GBS/sarcoid
In terms of prognosis 1/3 recover spontaneously, 1/3 recover after treatment with immunosupression and 1/3 develop renal failure.
Now on to another glomerulonephritis...
