MRCP revision battle 15.6: Klinefelters

Klinefelters is the commonest sex chromosome disorder, affecting roughly 1 in 1000 men.

Its karyotype is 47 XXY



The key features are:

• tall stature
• small testes
• azoospermia
• gynaecomastia

 Bloods show:

• low testosterone
• high LH/FSH

Treatment is with testosterone


Note there is increased risk of OP and breast cancer.


So on to the penultimate battle of the day, pellegra...