Sunday, 19 September 2010

MRCP revision battle 15.8: Neuroleptic malignant syndrome

Neuroleptic malignant syndrome is a condition that can complicate antipsychotic use. 

Its features are:
  • pyrexia
  • rigidity
  • tachycardia

Bloods show:
  • raised CK
  • leucocytosis
  • acidosis

It is commonest in young males, and onset is usually in the first 10 days of taking the drug or after the dose has been increased.

It is important not to miss as it has a 10% mortality.

Treatment is to stop the antipsychotic, give IV fluids, dantrolene and ?bromocriptine.

That's all for today, I'll catch up on the 'wars' tomorrow after I've caught up on sleep!